Here are 5 more mistakes to avoid when treating candida. These are all based on current and past science along with clinical observations by Dr. McCombs:

1)Lufenuron/Cell Wall Inhibitors

Lufenuron is a veterinarian medication to help control fleas in cats and dogs. The aim of the medication is to prevent the insects from forming a strong cell wall that consists of a substance called chitin. Researchers from the University of California, San Francisco, decided to look at whether or not lufenuron had any anti-fungal effects. They found, “No evidence of inhibition, either by susceptibility testing or direct microscopic examination of treated cells, was obtained with lufenuron“. In contrast, they showed that a known chitin synthesis inhibitor, Nikkomycin Z, had a potent inhibitory effect against chitin in fungal cell wall membranes. Their conclusion –  “lufenuron does not appear to possess anti-fungal properties”.

Since the amount of chitin found in the cell wall of candida is typically 0-20%, it doesn’t make sense to use this product in light of the risks involved.


An unexpected result of lufenuron treatment was the inhibition of midgut epithelial cell differentiation. At concentrations of 0.5 and 1.0 ppm, partially differentiated epithelial cells were seen in the midgut of blood-fed fleas along with fully differentiated cells.

Micrographs of ovaries, from animals treated with lufenuron, showed some space between the follicular epithelium and the oocyte membrane. The in vivo incorporation of radioactive N-acetylglucosamine into chitin was inhibited by the presence of lufenuron.…


Lufenuron bioaccumulates

The studies above demonstrate that lufenuron can cause intestinal cell line damage and leaky gut. One benefit of the intestinal cells is that they regenerate quickly, thus demonstrating their ability to heal and restore the intestinal barrier. Lufenuron has the ability to block this regeneration. It’s role in serine protease inhibition could lead to chronic inflammatory conditions, food allergies, autoimmune diseases, etc.
Lufenuron can also interfere with absorption of N-Acetylglucosamine, necessary for the formation of the cell walls in many beneficial bacteria.

Disturbance of the epithelial barrier and epithelial transport processes is often discussed to be a major factor in the pathogenesis of intestinal inflammation and inflammatory bowel disease.

Since Lufenuron acts like a serine protease inhibitor in the body, someone who was already deficient in serine proteases would face life-threatening issues. With about a third of the protein enzymes in the body being serine proteases, taking an inhibitor can work against health.

2) Turpentine

Turpentine is a common tool in the painter’s trade, as it used to clean brushes and rollers. It contains terpenes that are known to affect bacteria, fungus, parasites, and other microbes. Turpentine is one choice out there that some people have used to treat candida, although most people stay away from it due to the obvious toxicity concerns. While some people state that it’s not toxic, you have to take very small amounts into the body, or risk an emergency room visit.

Turpentine is one of those old-time remedies that have been used for various infections and illnesses for probably well over two hundred years, with some sources dating it as far back as biblical times. Turpentine has been shown to kill fungus, as well as bacteria, parasites, and just about everything else, and that’s where the problem lies. Destroying all of these microbes can create other imbalances. The killing of the bacteria is indiscriminate. Turpentine will eliminate good and bad bacteria, good and bad parasites, good and bad everything. There is no differentiation between bad and good microbes with turpentine and that’s a problem. Destroying the ecosystem balance leads to diseases and that’s how antibiotics create candida to begin with.

Turpentine’s ability to kill candida leads to the same imbalances caused by medications, namely that dead candida cells kill our immune cells – This is something that is never addressed by those who promote the use of turpentine.

There are safer and more effective choices for treating candida in today’s world. If you were living two hundred years ago, this may have been a good choice, but there are better options available today.

3) Enzymes 

Some people use enzymes believing that they will be able to break down candida’s cell wall, but if our body’s own enzyme producing factories can’t do this, then just taking store-bought enzymes won’t either. Candida has an amazing ability to alter the pH around its cells and enzymes are very dependent upon an optimum pH being present. The pH of tissues and fluids throughout the body varies greatly and this severely limits the effectiveness of enzymes against candida. Chitinase, a common enzyme found in formulas for candida, has its optimum activity at a pH of 4. At that pH, candida is found in its normal, beneficial yeast form, not its problematic fungal form. Therefore, such an enzyme would never address fungal candida and might provide a negative effect against the beneficial strains.

Enzymes are also affected by temperature and although this is more stable throughout the body, it’s a factor affecting the enzymes activity, especially when considering that very narrow temperature ranges are required.

Candida also has an amazing ability to shift the structure of its cell wall membrane very quickly when threatened by any outside substance. The use of medications against candida has proven this point as antifungal resistant strains of candida flourish after medication use. If you think enzymes are the answer to candida, think again.

4) Probiotics

Most people will be surprised to see this listed here, but it earns its right on this list when you consider that when you use probiotics is one of the most important factors in their ability to play a role in correcting fungal candida and restoring balance to the intestinal and body flora.

Most candida diets and practitioners start off with probiotics as part of their treatment approach.  Starting off a candida diet with the use of probiotics may be counter-productive. When antibiotics destroy the bacterial flora, the conversion of candida from its normal yeast state to its problematic fungal state takes place rapidly. With the fungal candida in place, and the re-population of the intestinal tract still many months away, candida takes over control of the intestinal tract. As bacteria begin to find their way back into the intestinal tract, candida regulates who grows back and who doesn’t.

One of the most important probiotic species needed for health are the Lactobacilli bacteria. They produce acids that help regulate pH and the growth of candida. Fungal candida makes sure that this species doesn’t grow back. As long as fungal candida is present, these species are inhibited from recolonizing the body and Lactobacilli are the main species found in most probiotic formulas. As long as fungal candida is present, these important bacteria may not be able to have the effect that they otherwise would.

I have found that successfully adding probiotics is best accomplished when most, if not all, of the fungal candida has been restored to its normal yeast form. Just as candida prevents the Lactobacillus bacteria from colonizing the body, once candida is corrected and there are re-established in the tissues, the Lactobacilli prevent candida from changing to its fungal form. Timing is very important.

5) Not Everything is Candida

Candida plays a role in creating over 125 different diseases and conditions in the body. Most of this is accomplished by the large amount of inflammation it creates and how inflammation is the basis for most conditions. That being said, we are also dealing with many other factors in our lives such as chemicals in our foods, waters, and air; heavy metals; various types of stress; medications and their residues; lack of nutrients; etc. If you’ve ever had antibiotics, then fungal candida will be a part of the problem, but it is almost never the whole problem. I’ve treated and talked to many people who think that all of their issues are candida, which can mislead them into thinking that they never seem to get well and they won’t when just pursuing one cause and not the others.

As re-establishing the right bacterial ratios in the gut and boosting the correct immune responses are so vital to health, I typically start there and then move on to the other issues, as having an intact bacterial flora makes addressing the other factors more effective. If you need to rebuild tissues in the body, being able to absorb the necessary nutrients is vital to recovery. The bacteria can also help to protect the body when moving other substances around to be eliminated.

As a parting note, I’m encountering more people who are too sick to do a diet, take supplements or medications, or follow a detoxification program. These people need to start elsewhere and that is where I’ve seen success in treating them, instead of believing that candida is the cause of everything. Later on , when they are healthier and able to eat more foods and take supplements, then the Candida Plan is often a good next step, but not everything is candida.

Avoiding the trap of these 5 mistakes can hurry you on your path top recovery and help to avoid wasting your time and money while your patience and health continue to fade. If you missed the first 5 Mistakes To Avoid When Treating candida, you can find that here –

For the best science-backed diet available, start the Candida Plan today!

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Dr. Jeffrey S. McCombs, DC, is founder of the McCombs Center for Health, the Candida Plan, the Candida Library, and author of LifeforceThe Everything Candida Book, and The Everything Guide to Autoimmune Diets. Check out our podcast, Candida Diet Tips Recipes, and Insights on Apple Podcast, Spotify, Google Podcasts, Amazon Music and Alexa Flash Briefings.

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