Best known for its role in allergic response, Histamine is produced by Mast cells in the body protects the body from potential disease-causing agents like bacteria, viruses and allergens. However, genetic variants can impact the body’s ability to break down excess histamine, creating symptoms throughout the body. In addition, there are foods naturally rich in histamine, as well as foods that signal the release of histamine, which again can lead to elevated histamine.the production of zonulin can be a contributing factor to autoimmune disease and leaky gut.